Seattle Genetics

Principal Scientist, Tumor Microenvironment (TME) Immunologist

Description

Seattle Genetics is an emerging multi-product, global biotechnology company that develops and commercializes transformative therapies targeting cancer to make a meaningful difference in people’s lives. ADCETRIS® (brentuximab vedotin) uses the company’s industry-leading antibody-drug conjugate (ADC) technology and is approved for the treatment of multiple CD30-expressing lymphomas.

Beyond ADCETRIS®, the company has established a pipeline of novel targeted therapies at various stages of clinical testing, including three in ongoing or planned pivotal trials for solid tumors. Enfortumab vedotin for metastatic urothelial cancer and tisotumab vedotin for metastatic cervical cancer use our proprietary ADC technology. Tucatinib, a small molecule tyrosine kinase inhibitor, is in a pivotal trial for HER2-positive metastatic breast cancer. In addition, we are leveraging our expertise in empowered antibodies to build a portfolio of proprietary immuno-oncology agents in clinical trials targeting hematologic malignancies and solid tumors.

Summary

Seattle Genetics is building a skilled immuno-oncology team and is seeking a highly motivated and innovative scientist with drug development experience to join our team. We are seeking an individual that is passionate about targeting stromal cells within the tumor microenvironment to advance cutting-edge oncology therapeutics from concept to clinical testing. The successful candidate will lead a team to advance our technology platforms and support development of novel oncology therapeutics. The candidate will evaluate pathways that regulate stromal components with an eye on identifying receptors and signaling pathways critical for eliciting anti-tumor responses. The candidate will leverage these insights and scientific expertise to propose strategies for therapeutic targeting.

Responsibilities:

• Provide scientific leadership within the immunology team and interface with other functional teams to discover novel therapeutics.
• Lead a cross-functional team to validate tumor microenvironment targets including stromal cell targets.
• Execute comprehensive experimental plans to enable project initiation and progression.
• Provide scientific and technical expertise to advance pre-clinical programs.
• Coach, mentor, and manage people for performance and scientific growth.
• Work independently, establish strategies, and identify actionable undertakings that drive projects within and outside the immunology team.

Requirements:

• A Ph.D. degree and 6+ years industry or academia experience in immunology, cellular and/or tumor immunology with a focus on stromal cells and the tumor microenvironment.
• Expertise in stromal cells is desired.
• History of leading cross-functional teams to advance ideas from concept to deliverable.
• Demonstrated ability to communicate complex data sets in a clear manner to drive initiatives involving internal and external stakeholders.
• Strong analytical, problem-solving, and decision-making skills as well as a record of accomplishments evidenced by publications/patents is required.
• Understanding of technological trends and demonstrated passion to develop innovative solutions.

As the leading employer in our industry in the Pacific Northwest, Seattle Genetics is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seattle Genetics, please visit www.seattlegenetics.com.

Seattle Genetics is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.

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Seattle Genetics

Seattle Genetics is an Equal Opportunity Employer

Submitted: 08/02/2019