Seagen

Scientist Discovery Proteomics

Research - Bothell, United States

Description

Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us!

Position Summary:

We are seeking a highly motivated proteomics scientist to join our Systems Biology team. The team aims to incorporate high-content, data-driven methods to enhance all aspects of our therapeutic pipeline. Our team has a deep interest in leveraging systems approaches to understand how tumors respond to and resist treatment so that we can drive increasingly durable clinical responses and better patient outcomes with our next generation of therapeutics. The successful candidate will have a deep understanding and expertise around proteomics assay design, execution, and analysis along with a vision for how proteomics tools can drive novel insights in therapeutic design. They will collaborate with an interdisciplinary team comprising chemists, engineers, pharmacologists, and biologists across the Research department to advance next-generation therapies in all areas of oncology. They will work closely with colleagues engaged in both preclinical and clinical stage programs to elucidate drug mechanisms of action, sensitivity, and resistance. The candidate will also support efforts to characterize tumor and target biology, working with early discovery teams to develop new hypotheses and therapeutic designs while building and democratizing foundational knowledge.

Principal Responsibilities:

• Lead the implementation of new proteomics assays and serve as a technical subject matter expert within Research
• Collaborate on cross-functional teams to support therapeutic discovery, design, and MOA studies
• Communicate findings through excellent written and oral communication and presentations
• Keep internal capabilities up to date with the field through conference attendance and external presentations

Required Qualifications:

• PhD with 0-2 years relevant experience; may include post-doctoral experience; or equivalent, such as M.S. with 6+ years relevant experience; Bachelor's degree with 8+ years relevant experience; Degree in related biology-focused field
• Broad understanding of mass spectrometry-based proteomics technology and intense curiosity and enthusiasm for applications within oncology drug development
• Significant direct experience in the design and implementation of proteomics assays along with working knowledge of respective data processing pipelines and downstream bioinformatics
• Track record of using proteomics assays to elucidate a biological system and generate novel insights
• General proficiency in a statistical programming language (e.g., R/Python)
• Outstanding communication and leadership skills, with a successful track record of collaboration within cross-functional teams
• Evidence of scientific independence through external publications or conference presentations

Preferred Qualifications:

• Experience with high-throughput sample preparation and DIA/SWATH acquisition schemes
• Experience with maintenance and operation of LC-MS systems
• Experience identifying protein-drug interactions using chemoproteomics (e.g., thermal profiling, affinity purification, limited proteolysis, covalent foot printing)
• Experience in analysis of post-translational modifications
• Understanding of cancer signaling pathways and mechanistic biology
• Understanding of drug development pipeline from target discovery through pre-clinical proof-of-concept and validation

As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit www.seagen.com.

The hiring pay range for this position is $65,000 to $84,700 per year based on skills, education and experience relevant to the role. Other components of total compensation include a competitive equity grant at the time of hire (with additional annual grants, and grants upon promotion when applicable), and an annual bonus.

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.

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Seagen

Seagen is an Equal Opportunity Employer

Submitted: 01/20/2023